Health benefit: Detox

Detox and cellular protection

Pollution, tobacco use, alcohol consumption, chronic stress, an unbalanced diet, and lack of sleep disrupt cellular balance and promote oxidative stress, accelerating aging and increasing the risk of chronic diseases.
Our bodies naturally defend themselves against these substances, known as xenobiotics, but these defense mechanisms have their limits.

Detox dietary supplements help strengthen the body’s natural defenses by supporting the elimination of toxic substances through the activation of detoxification pathways, thereby enhancing cellular protection. As a result, detoxification is one of the key drivers for optimizing longevity.

Detox supplements therefore represent a rapidly growing category, enabling reinforcement of the body’s natural defense systems and the promotion of long‑term health and longevity.

57% of consumers place greater importance on healthy aging than they did five years ago¹

+7.8% CAGR (2023–2033) for anti‑ROS supplements²

Why is supporting detoxification essential??

Oxidative stress occurs when the production of free radicals (ROS) exceeds the body’s capacity to neutralize them.

Consequences of oxidative stress

Cellular damage

Inflammation that becomes excessive and then chronic

Accelerated aging

Increased risk of chronic diseases

Nrf2, at the core of these mechanisms

At the heart of these mechanisms, the transcription factor Nrf2 (nuclear factor erythroid 2–related factor 2) plays a central role in antioxidant defenses.
It activates genes involved in the neutralization of free radicals and in the detoxification process through phase II detoxification enzymes.

Nrf2 activity declines with age

With aging or under the influence of external stressors, Nrf2 activity decreases, leading to:

Accumulation of cellular damage
Increased inflammation
Less efficient cellular repair

SULFODYNE® an effective active ingredient for detox & longevity

Clinical trials as well as in vitro and in vivo studies have shown that sulforaphane, the active component of SULFODYNE®, activates the Nrf2 pathway, enhancing cellular resilience, toxin elimination, and longevity. SULFODYNE® therefore plays a key role in the detoxification process.

Improved elimination of toxins

Upregulation of Phase II detoxification enzyme expression, including glutathione³˒⁴˒⁵
Enhancement of the body’s natural toxin elimination through urinary excretion³˒⁴

Enhanced atmospheric pollutants elimination

Elimination of environmental pollutants such as bisphenol A, heavy metals (cadmium, arsenic, mercury), and atmospheric pollutants (benzo[a]pyrene, acrolein, ethylene oxide, benzene)⁶˒⁷˒⁸˒⁹

Strengthening of antioxidant defenses and reduction of oxidative stress

Activation of the Nrf2 pathway, a key mechanism in cellular protection¹⁰
Protection of cells against free radicals¹⁰˒¹¹
Reduction of oxidative stress and inflammation¹⁰˒¹¹
Improvement of mitochondrial function and integrity, a key factor in combating oxidative stress¹²

Nutricosmestics properties

Protection against ultraviolet (UV)‑induced skin damage¹³˒¹⁴˒¹⁵ through:

- Reduction of reactive oxygen species (ROS)
- Inhibition of matrix metalloproteinase (MMP) expression
- Induction of Phase II cellular defense enzymes
Anti‑inflammatory and cytoprotective activity¹⁶ via:
- Increased expression of cytoprotective genes
- Reduced expression of inflammatory cytokines in the skin
Anti‑aging effect¹⁷ through:
- Activation of the apelin signaling pathway

Longevity and cellular energy

Cellular energy: improvement of mitochondrial function and integrity¹²
Extension of lifespan and healthspan in an aging C. elegans model¹⁸˒¹⁹
- Enhanced resistance to stres
- Delay of age‑related physiological decline
- Slowing of the transcriptional aging clock

References

1 : Nielsen, 2025 ; 2 : Growth Market Report, 2023 ; 3 :Boddupalli et al., 2012 ; 4 :Munday et al., 2008 ; 5 : Riedl et al., 2008 ; 6 : Cascajosa-Lira et al., 2024 ; 7 : Kensler et al., 2012 ; 8 : Egner et al., 2014 ; 9 : Chen et al., 2019 ; 10 : Roméo, et al.,2024 ; 11 : Chen M, et al., 2021 ; 12 : Holmström et al., 2016 ; 13 : Sikdar et al., 2016 ; 14 : Talay et al., 2007 ; 15 : Saw et al., 2014 ; 16 : Chien et al., 2025 ; 17 : Du et al., 2025 ; 18 : Qi et al., 2021 : 19 : Sedore et al., 2025

How to use SULFODYNE® into your food supplements?

Recommended dosage

100 mg/day* for one month

(*5 mg of stabilized sulforaphane)

3 dry galenic forms

Capsules, tablets, ready-to-mix powders

Target product segments

Longevity

Support for cellular protection against oxidative stress, helping preserve cells from damage linked to premature aging.

Detox

Support of the body’s natural defense and detoxification mechanisms, particularly hepatic, against environmental pollutants, toxins, and atmospheric contaminants, contributing to long‑term health maintenance.

Nutricosmetics

From protecting skin cells against environmental aggressors (pollution, UV exposure, free radicals) with antioxidant and detoxifying effects, to improving skin radiance and appearance.