Health benefit: Joint health
Joint Health: preserving daily mobility and comfort
Joints are complex structures composed of bones, muscles, ligaments, tendons, and connective tissues. With an aging population, increasing sedentary lifestyles, excess body weight, or regular physical activity, joints are subjected to repeated stress that can lead to pain, stiffness, reduced mobility, and inflammation. Joint disorders such as osteoarthritis or rheumatoid arthritis affect millions of people worldwide and represent a major public health challenge, with a significant impact on quality of life and long‑term mobility.
In 2021, 7.7% of the global population was affected by osteoarthritis, representing a 132% increase compared to 1990¹.
In France, one in two people experiences joint pain².
Why do joints become painful ?
With age, the body can enter a state of chronic low‑grade inflammation, which may contribute to the accelerated degradation of cartilage and alteration of joint tissues, leading to pain and reduced mobility³˒⁴.
This process is further intensified by:
- Oxidative stress
- Excess body weight
- Lack of physical activity
SULFODYNE® : an effective solution for joint health
The close links between inflammation, oxidative stress, and pain open the way to new therapeutic approaches. Several studies have demonstrated that, by activating the Nrf2 pathway, SULFODYNE®, standardized to 5% sulforaphane, acts in a comprehensive manner to restore redox balance, reduce inflammation, and thereby alleviate joint pain.
- Significant inhibition of the NF‑κB pathway, leading to a reduction in the production of pro‑inflammatory mediators⁵
- Significant decrease in the production of pro‑inflammatory prostaglandin E2 (PGE2), which is involved in inflammation and pain⁵
- Significant reduction of inflammation in an in vivo osteoarthritis model⁶
- Significant limitation of age‑related cartilage and bone degradation⁶
- Significant inhibition of matrix metalloproteinase (MMP) expression, enzymes involved in bone and cartilage breakdown⁵
- Significant reduction in joint pain and stiffness⁶
- Significant inhibition of cyclooxygenase enzymes COX‑1 and COX‑2, which play a key role in joint pain and inflammation⁵
References :
1 : Global Burden of Disease Study, 2021 ; 2 : Ifop, 2016 ; 3 : Loeser et al., 2016 ; 4 : Havelin & King, 2018 ; 5 : Choi et al., 2014 ; 6 : Moon et al., 2021
How to use SULFODYNE® into your food supplements?
Recommended dosage
100 to 200 mg per day* for 1 to 3 months
* (equivalent to 5 to 10 mg of stabilized sulforaphane)
3 dry galenic forms
Capsules, tablets, ready-to-mix powders
Target product segments
Osteoarthritis
Support for joint health by promoting optimal function of cartilage cells and contributing to the preservation of cartilage.
Rheumatoid Arthritis
Anti‑inflammatory action to support the body’s natural defense mechanisms against inflammatory rheumatic conditions.
Joint pain
Comprehensive support for joint comfort, helping to reduce sensations of discomfort and pain associated with the joints.
The science behind SULFODYNE®
Discover the scientific research and studies supporting the efficacy and bioavailability of SULFODYNE® 5% sulforaphane.
The Brccoli In Osteoarthritis (BRIO study) – A randomised controlled feasibility trial to examine the potential protective effect of broccoli bioactives, (specifically sulforaphane), on osteoarthritis
Davidson et al.
Nrf2 activation improves experimental rheumatoid arthritis, Free Radical Biology and Medicine
Anqi Zhang et al.
Sulforaphane protects against oxidative stressinduced apoptosis via activating SIRT1 in mouse osteoarthritis
Chen et al.
Discover the other benefits of SULFODYNE®
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