The science behind SULFODYNE®
Sulforaphane is a widely studied bioactive compound, supported by over 3,500 scientific publications and more than 90 clinical studies referenced on PubMed.
Scientific research has demonstrated its key role in activating the Nrf2 pathway, a fundamental mechanism involved in antioxidant defense, cellular protection, and inflammation regulation.
Thanks to these properties, sulforaphane plays a major role in protecting cells from aging and supporting long-term health and longevity. Its benefits extend across a wide range of health areas, including detoxification, glucose regulation, joint health, immune support, and women’s health.
As the active compound at the heart of SULFODYNE®, sulforaphane has been rigorously studied and continues to attract strong interest from the global scientific community.
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The broccoli derivative sulforaphane extends lifespan by slowing the transcriptional aging clock
Sedore et al.,
2025
Sulforaphane promotes C. elegans longevity and healthspan via DAF-16/DAF-2 insulin/IGF-1 signaling
Qi et al.,
2021
Integrative Network Pharmacology and Proteomics Decipher the Immunomodulatory Mechanism of Sulforaphane Against Intrinsic Skin Aging
Du et al.,
2025
Oral Glucoraphanin and Curcumin Supplements Modulate Key Cytoprotective Enzymes in the Skin of Healthy Human Subjects: A Randomized Trial
Chien et al.,
2025
Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation
Talay et al.,
2007
What do we know about sulforaphane protection against photoaging?
Sikdar et al.,
2016
The multifaceted role of Nrf2 in mitochondrial function
Holmström et al.,
2016
Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China
Egner et al.,
2014
Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China
Kensler et al.,
2012
Protective effects of sulforaphane against toxic substances and contaminants: A systematic review
Cascajosa-Lira et al.,
2024
Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway
Riedl et al.,
2008
Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial
Dwibedi et al.,
2025
Cruciferous vegetables improve glycaemic control compared to root/squash vegetables in a randomized, controlled, crossover trial: The VEgetableS for vaScular hEaLth (VESSEL) study
Connolly et al.,
2025
Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial
Bahadoran et al.,
2012
The Effects of Aerobic-Resistance Training and Broccoli Supplementation on Plasma Dectin-1 and Insulin Resistance in Males with Type 2 Diabetes
Saeidi et al.
2021
Natural Nrf2 activators in diabetes
Jimenez-Osorio et al.
2015
Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes
Axelsson et al.
2017
The Brccoli In Osteoarthritis (BRIO study) – A randomised controlled feasibility trial to examine the potential protective effect of broccoli bioactives, (specifically sulforaphane), on osteoarthritis
Davidson et al.
2024
Nrf2 activation improves experimental rheumatoid arthritis, Free Radical Biology and Medicine
Anqi Zhang et al.
2023
Sulforaphane protects against oxidative stressinduced apoptosis via activating SIRT1 in mouse osteoarthritis
Chen et al.
2021
The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory cytokines
Moon et al.
2021
Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation
Yang et al
2018
Sulforaphane Modulates Joint Inflammation in a Murine Model of Complete Freund’s Adjuvant-Induced Mono-Arthritis
Rodrigues et al.
2018
Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint
Davidson et al.
2017
Sulforaphane Inhibits IL-1β-Induced Proliferation of Rheumatoid Arthritis Synovial Fibroblasts and the Production of MMPs, COX-2, and PGE2
Choi et al.
2014
Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes
Fragoulis et al.
2012
Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate
Kong et al.
2010
Multiple Mechanisms of Action of Sulfodyne®, a Natural Antioxidant, against Pathogenic Effects of SARS-CoV-2 Infection
Romeo et al.
2024
Effects of sulforaphane glucosinolates from broccoli seed extract on the immune system of healthy Japanese adults
Kouno et al.
2023
Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice
Ordonez et al.
2021
Potential of Sulforaphane as a Natural Immune System Enhancer
Mahn et al.
2021
Effect of Broccoli Sprouts and Live Attenuated Influenza Virus on Peripheral Blood Natural Killer Cells: A Randomized, Double-Blind Study
Müller et al.
2016
Sulforaphane epigenetically regulates innate immune responses of porcine monocyte-derived dendritic cells induced with lipopolysaccharide
Qu et al.
2015
Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells
Kesic et al.
2011
Stimulation of phagocytosis by sulforaphane
Suganuma et al.
2011
Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea)
Thejass & Kuttan
2007
Antinociceptive and antiedema effects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane
Guadarrama-Enriquez et al.
2023
Anti-nociceptive and anti-inflammatory effects of sulforaphane on sciatic endometriosis in a rat model
Liu et al.
2020
Sulforaphane Attenuates Endometriosis in Rat Models Through Inhibiting PI3K/Akt Signaling Pathway
Zhou A et al.
2019
Anti-nociceptive and anti-inflammatory effects of sulforaphane on sciatic endometriosis in a rat mode
Liu et al.
2020
Sulforaphane Inhibited the Nociceptive Responses, Anxiety- and Depressive-Like Behaviors Associated With Neuropathic Pain and Improved the Anti-allodynic Effects of Morphine in Mice
Ferreira-Chamorro et al.
2018
Treatment with Sulforaphane Produces Antinociception and Improves Morphine Effects during Inflammatory Pain in Mice
Redondo et al.
2017
Nrf2 participates in depressive disorders through an anti-inflammatory mechanism
Martin-de-Saavedra et al., 2013.
2013
Effect of Administration of an Equal Dose of Selected Dietary Chemicals on Nrf2 Nuclear Translocation in the Mouse Liver
Alrawaiq et al.
2023
Sulforaphane protects against oxidative stressinduced apoptosis via activating SIRT1 in mouse osteoarthritis
Chen et al.
2021
The Integrative Role of Sulforaphane in Preventing Inflammation, Oxidative Stress and Fatigue: A Review of a Potential Protective Phytochemical
Ruhee & Suzuki
2020
Protective Effects of Sulforaphane on Exercise-Induced Organ Damage via Inducing Antioxidant Defense Responses
Ruhee & Suzuki
2020
Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress
Kubo et al.
2017
Nrf2 signaling pathway: Pivotal roles in inflammation
Ahmed et al.
2016
Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician’s Expectation Be Matched by the Reality?
Houghton et al.
2016
Induction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins A, C, and E
Boddupalli et al.
2012
Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China
Egner et al.
2011
Bioavailability of Sulforaphane Following Ingestion of Glucoraphanin-Rich Broccoli Sprout and Seed Extracts with Active Myrosinase: A Pilot Study of the Effects of Proton Pump Inhibitor Administration
Fahey et al.
2019
Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency
Fahey et al.
2017
Stabilized Sulforaphane for Clinical Use
Fahey et al.
2016
Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase
Fahey et al.
2015
Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway
Munday et al.
2008
A Double-Blind, Randomized, Crossover Study to Examine the Effect of a Probiotic on the Production and Bioavailability of Sulforaphane in Healthy Adults
Shapiro et al.
2006
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